A GP and lead of the DISCOVERY group in Exeter, Willie is also clinical lead for the 2015 NICE guidance, as well as a member of the Department of Health’s Policy Research Unit for cancer awareness, screening and early diagnosis.
Willie has been working on early cancer diagnosis for over twenty years. This began with studies that sought to identify and quantify the important features of cancer in a GP’s consulting room. This proceeded on a cancer site-by-site basis and mapped out the important features of colorectal cancer, then of lung, etc. Individual features were then tackled, e.g. what were the cancer risks from a raised calcium level or from thrombocytosis. Work then moved on to implementation, with adaptation of the teams outputs to GP computer systems and supporting NICE in collating NG12, the massive guidance on cancer investigation. This ongoing work has been supported by research grants from NIHR, CRUK, the Department of Health, and other charities.
Willie has won the cancer Research Paper of the Year several times, and the Overall Research Paper of the Year twice.
Follow Willie on Twitter @BoomboomchiefsT
+44 (0)7825 122330
University of Exeter, UK
Early diagnosis, at a local and at a system level
- Multi-parametric magnetic resonance imaging (mpMRI) for prostate cancer diagnosis in primary care
- International comparison of FIT use across the globe in primary care symptomatic patients: A narrative view
- Establishing the diagnostic accuracy of haemoglobin in faecal immunochemical tests (FITs) and establishing a receiver operating characteristic (ROC) curve for FITs in the English primary care symptomatic population: A cohort study in the South West of England
- Establishing the diagnostic accuracy, acceptability and cost-effectiveness of haemoglobin in faecal immunochemical tests (FITs) in the English primary care symptomatic population: a cohort study in the East of England
- Understanding missed diagnostic opportunities in bladder and kidney cancer
- What is the clinical-effectiveness and cost-effectiveness of embedded risk-of-cancer assessment of patients in primary care; the ERICA trial
- International dataset inventory for the CanTest collaborative
- The role of imaging in the diagnosis of symptomatic lung cancer
- The diagnostic utility of inflammatory markers in primary care: a prospective cohort study
- Tests and tools for the detection of ovarian cancer in primary care
- Abdominal pain in primary care: establishing a clinical profile and diagnostic pathway for identifying cancer
- Evaluating the impact of NICE guidelines for suspected cancers in respect of diagnostic interval and other outcomes
- Aids to cancer diagnosis in primary care
- Are patients with high normal platelet counts at increased risk of cancer?
- Guideline discordant diagnostic care: when do referrals not reflect guidelines for suspected cancer?
- Exploring patient, practitioner and general population preferences towards diagnostic tests for cancer
- Risk of lung cancer in symptomatic patients with negative chest x-ray results
- Impact of decision tools for early cancer diagnosis in general practice on GP workload and patient ‘flow’ during consulting sessions (PhD)
- What factors influence GPs’ decision to request imaging for possible lung cancer?
- AI technologies for cancer detection in primary care
- Ozawa M, Brennan PM, Zienius K, Kurian KM, Hollingworth W, Weller D, Hamilton W, Grant R, Ben-Shlomo Y. Symptoms in primary care with time to diagnosis of brain tumours. Family Practice, 2018: 1-8
- Stanciu MA, Law R-J, Nafees S, Hendry M, Yeo ST, Hiscock J, Lewis R, Edwards RT, Williams NH, Brain K, Brocklehurst P, Carson-Stevens A, Dolwani S, Emery J, Hamilton W, Hoare Z, Lyratzopoulos G, Rubin G, Smits S, Vedsted P, Walter FM, Wilkinson C, Neal RD. Development of an intervention to expedite cancer diagnosis through primary care: Protocol. BJGP Open 4 September 2018; bjgpopen18X101595
- Renzi C, Lyratzopoulos G, Hamilton W, Rachet B. Opportunities for reducing emergency diagnoses of colon cancer in women and men: a data-linkage study on pre-diagnostic symptomatic presentations and benign diagnoses. Eur Journal Cancer Care. 2019. e13000. doi: 10.1111/ecc.13000
- Mendonca SC, Abel GA, Gildea C, McPhail S, Peake MD, Rubin G, Singh H, Hamilton W, Walter FM, Roland MO, Lyratzopoulos G. Associations between general practice characteristics with use of urgent referrals for suspected cancer and endoscopies: a cross-sectional ecological study. Family Practice, 2018, cmy118
- Walter FM, Penfold C, Joannides A, Saji S, Johnson M, Watts C, Brodbelt A, Jenkinson MD, Price SJ, Hamilton W, Scott SE. Missed opportunities for diagnosing brain tumours in primary care: a qualitative study of patient experiences. Br J Gen Pract, 2019, bjgp19X701861. DOI: 10.3399/bjgp19X70186