Publications

Below is a list of all CanTest publications that acknowledge the support of Cancer Research UK:

  1. Carney M, Quiroga M, Mounce L, Shephard E, Hamilton W, Price S. Effect of pre-existing conditions on bladder cancer stage at diagnosis: a cohort study using electronic primary care records in the UK. British Journal of General Practice, 2020. doi: 10.3399/bjgp20X710921
  2. di Martino E, Andersen AC, Mengel-Jørgensen T, Jensen MB, Bradley S, Neal RD. Is there a place for point-of-care ultrasound in UK primary care? British Journal of General Practice, 2020; 70 (696): 323-324. doi: 10.3399/bjgp20X710801
  3. Hopkins R, Bailey SER, Hamilton WT, Shephard EA. Microcytosis as a risk marker of cancer in primary care: a cohort study using electronic patient records. British Journal of General Practice, 2020; 70 (696): e457-e462. doi: 10.3399/bjgp20X709577
  4. Lyratzopoulos G, Abel GA. Assessing patients at risk of symptomatic-but-as-yet-undiagnosed cancer in primary care using information from patient records. Br J Cancer. 2020, Jun;122(12):1729-1731.. doi: 10.1038/s41416-020-0828-4
  5. Sarma EA, Kobrin SC, Thompson MJ. A Proposal to Improve the Early Diagnosis of Symptomatic Cancers in the US. Cancer Prevention Research, 2020, doi: 10.1158/1940-6207.CAPR-20-0115.
  6. van Melle M, Yep Manzano S, Wilson H, Hamilton W, Walter FM, Bailey SER. Faecal immunochemical test to triage patients with abdominal symptoms for suspected colorectal cancer in primary care: review of international use and guidelines. Family Practice, 2020. doi: 10.1093/fampra/cmaa043
  7. Jones D, Neal RD, Duffy SRG, Scott SE, Whitaker KL, Brain K. Impact of the COVID-19 pandemic on the symptomatic diagnosis of cancer: the view from primary care. The Lancet Oncology, 2020, doi: 10.1016/S1470-2045(20)30242-4
  8. Zhou Y, Abel GA, Hamilton W, Singh H, Walter FM, Lyratzopoulos G. Imaging activity possibly signalling missed diagnostic opportunities in bladder and kidney cancer: A longitudinal data-linkage study using primary care electronic health recordsCancer Epidemiology, 2020, doi: 10.1016/j.canep.2020.101703
  9. Merriel SWD, Hardy V, Thompson M, Walter FM, Hamilton W. Patient-centered outcomes from multiparametric magnetic resonance imaging (mpMRI) and MRI-guided biopsy for prostate cancer: A systematic review. Journal of the American College of Radiology Volume 17, Issue 4, April 2020, Pages 486-495, doi.org/10.1016/j.jacr.2019.08.031
  10. Walter FM, Pannebakker MP, Barclay ME, Mills K, Saunders CL, Murchie P, Corrie P, Hall P, Burrows N, Emery JD. Effect of a Skin Self-monitoring Smartphone Application on Time to Physician Consultation Among Patients With Possible Melanoma: A Phase 2 Randomized Clinical Trial. JAMA Network Open, 2020, doi: 10.1001/jamanetworkopen.2020.0001
  11. Habgood E, Walter FM, O’Hare E, McIntosh J, McCormack C, Emery JD. Using an electronic self-completion tool to identify patients at increased risk of melanoma in Australian primary care. Austalasian Journal of Dermatology, 2020, doi: 10.1111/ajd.13244
  12. Chowienczyk S, Price S, Hamilton W. Changes in the presenting symptoms of lung cancer from 2000–2017: a serial cross-sectional study of observational records in UK primary care. British Journal of General Practice, 2020, doi: 10.3399/bjgp20X708137
  13. Pearson C, Poirier V, Fitzgerald K, Rubin G, Hamilton W. Cross-sectional study using primary care and cancer registration data to investigate patients with cancer presenting with non-specific symptoms. BMJ Open, 2020, doi: 10.1136/bmjopen-2019-033008
  14. Murphy DR., Giardina TD, Satterly T, Sittig DF, Singh H. An Exploration of Barriers, Facilitators, and Suggestions for Improving Electronic Health Record Inbox-Related Usability. A Qualitative Analysis. JAMA Network Open, 2019, 2(10):e1912638, doi:10.1001/jamanetworkopen.2019.12638
  15. Rafiq M, Hayward A, Warren-Gash C, Denaxas S, Gonzalez-Izquierdo A, Lyratzopoulos G, Thomas S. Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study. Journal of Allergy and Clinical Immunology, 2019, doi: 10.1016/j.jaci.2019.10.033
  16. Watson J, Jones HE, Banks J, Whiting P, Salisbury C, Hamilton W. Use of multiple inflammatory marker tests in primary care: using Clinical Practice Research Datalink to evaluate accuracy. British Journal of General Practice, 2019, doi: 10.3399/bjgp19X704309
  17. Watson J, Salisbury C, Whiting P, Banks J, Pyne Y, Hamilton W. Added value and cascade effects of inflammatory marker tests in UK primary care: a cohort study from the Clinical Practice Research Datalink. British Journal of General Practice, 2019, doi: 10.3399/bjgp19X704321
  18. Round T, Abel G. Seeing the wood and the trees: the impact of the healthcare system on variation in primary care referrals. BMJ Quality & Safety, 2019, 0:1-3, doi: 10.1136/bmjqs-2019-010356
  19. Swann R, Lyratzopoulos G, Rubin G, Pickworth E, McPhail S. The frequency, nature and impact of GP-assessed avoidable delays in a population-based cohort of cancer patients. Cancer Epidemiology, 2019, doi: 10.1016/j.canep.2019.101617
  20. Chima S, Reece JC, Milley K, Milton S, McIntosh JG, Emery J. Decision support tools to improve cancer diagnostic decision making in primary care: a systematic review. British Journal of General Practice, 2019, doi: 10.3399/bjgp19X706745
  21. Jones OT, Ranmuthu CKI, Hall PN, Funston G, Walter FM. Recognising Skin Cancer in Primary Care. Advances in Therapy, 2019, 1-14, doi: 10.1007/s12325-019-01130-1
  22. Koo MM, Swann R, McPhail S, Abel GA, Elliss-Brookes L, Rubin GP, Lyratzopoulos G. Presenting symptoms of cancer and stage at diagnosis: evidence from a cross-sectional, population-based study. The Lancet Oncology, 2019, doi: 10.1016/S1470-2045(19)30595-9
  23. Funston G, Van Melle M, Ladegaard Baun M-L, Jensen H, Helsper C, Emery J, Crosbie EJ, Thompson M, Hamilton W, Walter FM. Variation in the initial assessment and investigation for ovarian cancer in symptomatic women: a systematic review of international guidelines. BMC Cancer, 2019, 19:1028 doi:10.1186/s12885-019-6211-2
  24. Smith AF, Shinkins B, Hall PS, Hulme CT, Messenger MP. Towards a framework for outcome-based analytical performance specifications: a methodology review of indirect methods for evaluating the impact of measurement uncertainty on clinical outcomesClinical Chemistry,65:11 (1363-1374), doi: 10.1373/clinchem.2018.300954
  25. Herbert A, Winters S, McPhail S, Elliss-Brookes L, Lyratzopoulos G, Abel G. Population trends in emergency cancer diagnoses: The role of changing patient case-mix. Cancer Epidemiology, 63, doi: 10.1016/j.canep.2019.101574
  26. Bradley SH, Abraham S, Callister M, Grice A, Hamilton W, Rodriguez Lopez R, Shinkin B, Neal R. Sensitivity of chest x-ray for detecting lung cancer in people presenting with symptoms: systematic review. British Journal of General Practice, 2019, doi: 10.3399/bjgp19X706853
  27. Watson J, Mounce L, Bailey SER, Cooper SL, Hamilton W. Blood markers for cancer. British Medical Journal, 2019, 367:l5774, doi: 10.1136/bmj.l5774
  28. Zhou Y, van Melle M, Singh H, Hamilton W, Lyratzopoulos G, Walter FM. Quality of the Diagnostic Process in Patients Presenting with Symptoms Suggestive of Bladder or Kidney Cancer: A Systematic Review. British Medical Journal Open, 2019, 2019;9:e029143. doi: 10.1136/bmjopen-2019-029143
  29. Nicholson BD, Aveyard P, Hamilton W, Hobbs FDR. When should unexpected weight loss warrant further investigation to exclude cancer? British Medical Journal, 2019, 366:l5271, doi: 10.1136/bmj.l5271
  30. Singh H, Khanna K, Spitzmueller C, Meyer AND. Recommendations for using the Revised Safer Dx Instrument to help measure and improve diagnostic safety. Diagnosis, 2019. pii: /j/dx.ahead-of-print/dx-2019-0012/dx-2019-0012.xml. doi: 10.1515/dx-2019-0012
  31. Koo MM, Rubin G, McPhail S, Lyratzopoulos G. Incidentally diagnosed cancer: population-based evidence on frequency, variation, and commonly preceding clinical scenarios. BMJ Open, 2019, 9:e028362
  32. Herbert A, Abel GA, Winters S, McPhail S, Elliss-Brookes L, Lyratzopoulos G. Cancer diagnoses after emergency GP referral or A&E attendance in England: Determinants and time trends in Routes to Diagnosis data, 2006–2015. BJGP, 2019, bjgp19X705473
  33. Jones OT, Jurascheck LC, van Melle MA, Hickman S, Burrows NP, Hall PN, Emery J, Walter FM. Dermoscopy for melanoma detection and triage in primary care: a systematic review. BMJ Open, 2019, 9:e027529
  34. Elwenspoek MMC, Sheppard AL, McInnes MDF, Merriel SWD, Rowe EWJ, Bryant RJ, Donovan JL, Whiting P. Comparison of multiparametric magnetic resonance imaging and targeted biopsy with systematic biopsy alone for the diagnosis of prostate cancer: A systematic review and meta-analysis. JAMA Network Open, 2019, 2(8):e198427
  35. Moodley J, Scott SE, Mwaka AD, Constant D, Githaiga JN, Stewart TS, Payne A, Cairncross L, Somdyala NIM, Walter FM. Development and validation of the African Women Awareness of CANcer (AWACAN) tool for breast and cervical cancer. PLoS ONE, 2019, 14(8):e0220545
  36. Renzi C, Kaushal A, Emery J, Hamilton W, Neal RD, Rachet B, Rubin G, Singh H, Walter FM, de Wit NJ, Lyratzopoulos G. Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms. Nature Reviews: Clinical Oncology, 2019, https://doi.org/10.1038/s41571-019-0249-6
  37. Amelung D, Whitaker KL, Lennard D, Ogden M, Sheringham J, Zhou Y, Walter FM, Singh H, Vincent C, Black G. Influence of doctor-patient conversations on behaviours of patients presenting to primary care with new or persistent symptoms: a video observation study. BMJ Quality & Safety, https://doi.org/10.1136/bmjqs-2019-009485
  38. Walter FM, Thompson MJ, Wellwood I, Abel GA, Hamilton W, Johnson M, Lyratzopoulos G, Messenger MP, Neal RD, Rubin G, Singh H, Spencer A, Sutton S, Vedstead P, Emery JD. Evaluating diagnostic strategies for early detection of cancer: the CanTest framework. BMC Cancer, 2019, 19:586
  39. Pearson C, Fraser J, Peake M, Valori R, Poirier V, Coupland VH, Hiom S, McPhail S, Moffat J, Lyratzopoulos G, Shelton J. Establishing population-based surveillance of diagnostic timeliness using linked cancer registry and administrative data for patients with colorectal and lung cancer. Cancer Epidemiology, 2019, 61:111-118
  40. Neal RD, Sun F, Emery JD, Callister ME. Lung Cancer. BMJ, 2019, 365:I1725
  41. Renzi C, Lyratzopoulos G, Hamilton W, Maringe C, Ratchet B. Contrasting effects of comorbidities on emergency colon cancer diagnosis: a longitudinal data-linkage study in England. BMC Health Services Research, 2019; 19:311
  42. Baun ML, Jensen H, Falborg AZ, Heje HN, Petersen LK, Vedsted P. Ovarian cancer suspicion, urgent referral and time to diagnosis in Danish general practice: a population-based study. Family Practice, 2019, cmz013
  43. Watson J, Salisbury C, Banks J, Whiting P, Hamilton W. Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records. British Journal of Cancer, 2019, 120:1045-1051
  44. Jones OT, Jurascheck LC, Utukuri M, Pannebakker MM, Emery J, Walter FM. Dermoscopy use in UK primary care: a survey of GPs with a special interest in dermatology. Journal of the European Academy of Dermatology and Venereology, 2019, https://doi.org/10.1111/jdv.15614
  45. Murphy DR, Satterly T, Rogith D, Sittig DF, Singh H. Barriers and facilitators impacting reliability of the electronic health record-facilitated total testing process. International Journal of Medical Informatics, 2019, 127: 102-108
  46. Zhou Y, Funston G, Lyratzopoulos G, Walter FM. Improving the Timely Detection of Bladder and Kidney Cancer in Primary Care. Advances in Therapy, 2019, https://doi.org/10.1007/s12325-019-00966-x
  47. Walter FM, Penfold C, Joannides A, Saji S, Johnson M, Watts C, Brodbelt A, Jenkinson MD, Price SJ, Hamilton W, Scott SE. Missed opportunities for diagnosing brain tumours in primary care: a qualitative study of patient experiences. Br J Gen Pract, 2019, bjgp19X701861. DOI: 10.3399/bjgp19X70186
  48. Scott SE, Penfold C, Saji S, Curtis S, Watts C, Hamilton W, Joannides AJ, Walter FM. ‘It was nothing that you would think was anything’: Qualitative analysis of appraisal and help seeking preceding brain cancer diagnosis. PLoS ONE, 2019, 14:3, e02135
  49. Renzi C, Lyratzopoulos G, Hamilton W, Rachet B. Opportunities for reducing emergency diagnoses of colon cancer in women and men: a data-linkage study on pre-diagnostic symptomatic presentations and benign diagnoses. Eur Journal Cancer Care. 2019. e13000. doi: 10.1111/ecc.13000
  50. Mendonca SC, Abel GA, Gildea C, McPhail S, Peake MD, Rubin G, Singh H, Hamilton W, Walter FM, Roland MO, Lyratzopoulos G. Associations between general practice characteristics with use of urgent referrals for suspected cancer and endoscopies: a cross-sectional ecological study. Family Practice, 2018, cmy118
  51. Bradley SH, Kennedy MPT, Neal R. Recognising Lung Cancer in Primary Care. Advances in Therapy 2018; 1-12
  52. Herbert A, Abel GA, Winters S, McPhail S, Elliss-Brookes L, Lyratzopoulos G. Are inequalities in cancer diagnosis through emergency presentation narrowing, widening or remaining unchanged? Longitudinal analysis of English population-based data 2006-2013. J Epidemiol Community Health, 2019, 73(1): 3-10
  53. Nicholson BD, Perera R, Thompson MJ. Editorials: The elusive diagnosis of cancer: Testing times. British Journal of General Practice, 2018, 68:676, 510-511
  54. Stanciu MA, Law R-J, Nafees S, Hendry M, Yeo ST, Hiscock J, Lewis R, Edwards RT, Williams NH, Brain K, Brocklehurst P, Carson-Stevens A, Dolwani S, Emery J, Hamilton W, Hoare Z, Lyratzopoulos G, Rubin G, Smits S, Vedsted P, Walter FM, Wilkinson C, Neal RD. Development of an intervention to expedite cancer diagnosis through primary care: Protocol. BJGP Open 4 September 2018; bjgpopen18X101595
  55. Lyratzopoulos G. Electronic patient records research to aid diagnostic reasoning for possible cancer in primary care. Br J Gen Pract 2018; 68 (674): 408-409
  56. Maringe C, Rachet B, Lyratzopoulos G, Rubio FJ. Persistent inequalities in unplanned hospitalisation among colon cancer patients across critical phases of their care pathway, England, 2011–13. British Journal of Cancer, 2018, 119:5, 551-557
  57. Herbert A, Koo MM, Barclay ME, Greenberg DC, Abel GA, Levell NJ, Lyratzopoulos G. Stage-specific incidence trends of melanoma in an English region, 1996–2015: longitudinal analyses of population-based data. Melanoma Research, 2018. doi: 10.1097/CMR.0000000000000489
  58. Forster AS, Renzi C, Lyratzopoulos G. Diagnosing cancer in patients with ‘non-alarm’ symptoms: Learning from diagnostic care innovations in Denmark. Cancer Epidemiology, 2018; 54, 101-103
  59. Salika T, Abel GA, Mendonca SC, von Wagner C, Renzi C, Herbert A, McPhail S, Lyratzopoulos G. Associations between diagnostic pathways and care experience in colorectal cancer: evidence from patient-reported data. Frontline Gastroenterology 2018;9:241-248
  60. Kwan JL, Singh H. General Internists in Pursuit of Diagnostic Excellence in Primary Care: a #ProudtobeGIM Thread That Unites Us All. Journal of General Internal Medicine, 33(4): 395-396
  61. Ozawa M, Brennan PM, Zienius K, Kurian KM, Hollingworth W, Weller D, Hamilton W, Grant R, Ben-Shlomo Y. Symptoms in primary care with time to diagnosis of brain tumours. Family Practice, 2018: 1-8
  62. Rubin G, Walter FM, Emery J, and de Wit N. Reimagining the diagnostic pathway for gastro-intestinal cancer. Nature Reviews Gastroenterology and Hepatology, 2018; doi:10.1038/nrgastro.2018.1
  63. Herbert A, Lyratzopoulos G., Whelan J., Taylor R.M., Barber J., Gibson F., Fern L.A. Diagnostic timeliness in adolescents and young adults with cancer: a cross-sectional analysis of the BRIGHTLIGHT cohort. The Lancet Child and Adolescent Health, 2018; 2(3): 180-190