Dr Sam Merriel

Faculty

Sam is a GP and CanTest Clinical Research Fellow. His PhD will focus on assessing the safety, acceptability and cost-effectiveness of MRI scans for prostate cancer diagnosis in primary care. His research interests include early detection of cancer in primary care, application of genomics in primary care, and preventive medicine.

Sam is also a member of the active surveillance expert reference group for Prostate Cancer UK.

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Institution

University of Exeter, UK

Areas of Expertise

Clinical research, prostate cancer, cancer prevention

Projects

Publications

Merriel SWD, Martins T, Bailey SER. Exploring the Causes of Death Among Patients With Metastatic Prostate Cancer – A Changing Landscape. JAMA Network Open, 4(8):e2120889
Sheppard AL, McInnes MDF, Merriel SWD, Rowe EWJ, Bryant RJ, Donovan JL, Whiting P. Comparison of multiparametric magnet resonance imaging and targeted biopsy with systematic biopsy alone for the diagnosis of prostate cancer: A systematic review and meta-analysis. JAMA Network Open, 2019, 2(8):e198427
Merriel SWD, Hardy V, Thompson M, Walter FM, Hamilton W. Patient-centered outcomes from multiparametric magnetic resonance imaging (mpMRI) and MRI-guided biopsy for prostate cancer: A systematic review. Journal of the American College of Radiology, 2019, S1546-1440(19)31032-4
Martins T, Merriel SWD, Hamilton W. Routes to diagnosis of symptomatic cancer in sub-Saharan Africa: systematic review. BMJ Open, 2020;10:e038605. doi: 10.1136/bmjopen-2020-038605
Merriel SWD, Moon, D; Dunde, P; Corcoran, N; Carroll, P; Partin, A; Smith, J A; Hamdy, F; Moore, C; Ost, P; Costello, T. A modified Delphi study to develop a practical guide for selecting patients with prostate cancer for Active Surveillance. BMC Urology, 2021; 21:18, doi: 10.1186/s12894-021-00789-5
Merriel SWD, Hamilton W. Improving early cancer diagnosis in primary care. Prescriber, 2020, 31:9, 10-14, doi: 10.1002/psb.1862
Merriel SWD, Ingle SM, May MT, Martin RM. Retrospective cohort study evaluating clinical, biochemical and pharmacological prognostic factors for prostate cancer progression using primary care data. BMJ Open, 2021;11:e044420. doi 10.1136/bmjopen-2020-044420
Merriel SWD, Pocock L, Gilbert E, Creavin S, Walter FM, Spencer A, Hamilton W. Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients. BMC Med 20, 54 (2022). doi: 10.1186/s12916-021-02230-y
Merriel SWD, Lee L, Neal R. Community diagnostic centres: Bringing diagnostics closer to home. British Journal of General Practice 2021; 71 (713): 534-535. doi: 10.3399/bjgp21X717701
Merriel SWD. Lymphoma for GPs across the cancer continuum. InnovAiT. January 2022. doi: 10.1177/17557380211066121
Hardy V, Yue A, Archer S, Merriel SWD, Thompson M, Emery J, Usher-Smith J, Walter FM. Role of primary care physician factors on diagnostic testing and referral decisions for symptoms of possible cancer: a systematic review. BMJ Open 2022;12:e053732. doi: 10.1136/bmjopen-2021-053732
Merriel SWD, Ball S, Bright CJ, Mak V, Gildea C, Paley L, Hyde C, Hamilton W, Elliss-Brookes L. (2022). A prospective evaluation of the fourth national Be Clear on Cancer ‘Blood in Pee’ campaign in England. European Journal of Cancer Care, 1– 11. doi: 10.1111/ecc.13606
Merriel SWD, Archer S, Forster AS, Eldred-Evans D, McGrath J, Ahmed HU, Hamilton W, Walter FM. Experiences of ‘traditional’ and ‘one-stop’ MRI-based prostate cancer diagnostic pathways in England: a qualitative study with patients and GPs. BMJ Open 2022; 12:e054045. doi: 10.1136/bmjopen-2021-054045
Green HD, Merriel SWD, Oram RA, Ruth KS, Tyrrell J, Jones SE, Thirlwell C, Weedon MN, Bailey SER. Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank. Br J Cancer 127, 1534–1539 (2022). doi: 10.1038/s41416-022-01918-z
Barlow M, Down L, Mounce LTA, Merriel SWD, Watson J, Martins T, Bailey SER. Ethnic differences in prostate-specific antigen levels in men without prostate cancer: a systematic review. Prostate Cancer Prostatic Dis. 2022 Dec 1. doi: 10.1038/s41391-022-00613-7